Phenotypes Associated with This Genotype

Genotype
MGI:3652420

• Allelic Composition: Tg(Ckm-Cd36)1Naa/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:57650 )

• exhibit less overall body fat, however fat tissue distribution is not altered and do not show neutral lipid depots in myocardium or skeletal muscle

growth/size/body

decreased body weight ( J:57650 )

• exhibit smaller body weight during the first 6 months of growth

homeostasis/metabolism

increased circulating glucose level ( J:57650 )

• glucose levels are increased by about 30% in both the fed and fasted states

increased circulating insulin level ( J:57650 )

• insulin levels are normal in fed mice but are increased about 2-fold after an overnight fast

decreased circulating cholesterol level ( J:57650 )

• plasma cholesterol is about 11% lower, however cholesterol levels are not changed by fasting and no change is seen in the cholesterol content of lipoprotein fractions

decreased circulating free fatty acids level ( J:57650 )

• plasma fatty acid levels are lower with the difference most apparent after an overnight fast

decreased circulating triglyceride level ( J:57650 )

• about 30% lower triglyceride levels

decreased circulating VLDL triglyceride level ( J:57650 )

• the decrease in blood triglyceride levels is pronounced in the VLDL fraction, which lost 40% of its triglyceride content

muscle

abnormal muscle physiology ( J:57650 )

• soleus muscle exhibits a higher ability to oxidize fatty acid in response to contraction than in controls