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Phenotypes Associated with This Genotype
Genotype
MGI:3652413
Allelic
Composition
Fbn2tm1Rmz/Fbn2tm1Rmz
Genetic
Background
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn2tm1Rmz mutation (0 available); any Fbn2 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Bilateral syndactyly in Fbn2tm1Rmz/Fbn2tm1Rmz mice

limbs/digits/tail
• at E13.5 decreased apoptosis is seen in the interdigital rays
• malformed at E13.5 before the appearance of interdigital cell death
• bilateral syndactyly involving the central 2 or 3 digits of both the hind and fore paws and always involving the first phalange

skeleton
• newborns have contractures of the carpal, metacarpal, and phalangeal joints in the forelimbs; however these disappear within the first few days of life
• large joints of the hindlimbs appear to be stiffer compared to wild-type littermates

respiratory system
N
• branching morphogenesis of the lungs is normal

cellular
• at E13.5 decreased apoptosis is seen in the interdigital rays

Mouse Models of Human Disease
OMIM ID Ref(s)
Arthrogryposis, Distal, Type 9; DA9 121050 J:70592


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory