Mouse Genome Informatics
hm
    Fbn2tm1Rmz/Fbn2tm1Rmz
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Bilateral syndactyly in Fbn2tm1Rmz/Fbn2tm1Rmz mice

limbs/digits/tail
• at E13.5 decreased apoptosis is seen in the interdigital rays
• malformed at E13.5 before the appearance of interdigital cell death
• bilateral syndactyly involving the central 2 or 3 digits of both the hind and fore paws and always involving the first phalange

skeleton
• newborns have contractures of the carpal, metacarpal, and phalangeal joints in the forelimbs; however these disappear within the first few days of life
• large joints of the hindlimbs appear to be stiffer compared to wild-type littermates

respiratory system
N
• branching morphogenesis of the lungs is normal (J:70592)

cellular
• at E13.5 decreased apoptosis is seen in the interdigital rays

Mouse Models of Human Disease
OMIM IDRef(s)
Arthrogryposis, Distal, Type 9; DA9 121050 J:70592