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Phenotypes Associated with This Genotype
Genotype
MGI:3652404
Allelic
Composition		 Casttm1Tcs/Casttm1Tcs
Genetic
Background		 B6.129-Casttm1Tcs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casttm1Tcs mutation (1 available); any Cast mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to neuronal excitotoxicity ( J:109976 )
• Cast deficiency results in augmented DNA fragmentation in CA1 pyramidal neurons 24 hours after excitotoxic kainate treatment

homeostasis/metabolism
increased susceptibility to neuronal excitotoxicity ( J:109976 )
• Cast deficiency results in augmented DNA fragmentation in CA1 pyramidal neurons 24 hours after excitotoxic kainate treatment

cellular
increased susceptibility to neuronal excitotoxicity ( J:109976 )
• Cast deficiency results in augmented DNA fragmentation in CA1 pyramidal neurons 24 hours after excitotoxic kainate treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory