Phenotypes Associated with This Genotype

Genotype
MGI:3641317

• Allelic Composition: Tbx1^tm1Bld/Tbx1^{tm1(Fgf8)Vite}
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal pharyngeal arch morphology ( J:110620 )

• at E10.5, embryos show an abnormal pharynx lacking caudal arches

absent pharyngeal arch arteries ( J:110620 )

• arch arteries are absent at E10.5

craniofacial

abnormal pharyngeal arch morphology ( J:110620 )

• at E10.5, embryos show an abnormal pharynx lacking caudal arches

absent pharyngeal arch arteries ( J:110620 )

• arch arteries are absent at E10.5

cardiovascular system

absent pharyngeal arch arteries ( J:110620 )

• arch arteries are absent at E10.5

double aortic arch ( J:110620 )

• one fetus had double aortic arch with aortic dilation

persistent truncus arteriosus ( J:110620 )

• PTA associated with the right or left aortic arch is observed at E18.5; in all affected mutants, PTA communicates solely with the right ventricle

abnormal interventricular septum morphology ( J:110620 )

• a ventricular septal defect is observed

abnormal semilunar valve morphology ( J:110620 )

• there is a loss of continuity between the mitral and semilunar valves