Phenotypes Associated with This Genotype

Genotype
MGI:3641262

• Allelic Composition: Atp2b2^m1Mae/Atp2b2^m1Mae; Pparg^tm2Mae/Pparg^tm2Mae
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal reflex ( J:110607 )

abnormal blinking ( J:110607 )

• absent eye blink reflex

absent pinna reflex ( J:110607 )

impaired righting response ( J:110607 )

• when attempting to right themselves mice frequently fall on their side and turn onto their back with alternating flexion and hypertonic musculature of the extremities

• righting takes more than 4 sec compared to 0-1 sec in wild-type mice

absent startle reflex ( J:110607 )

• no response to acoustic stimuli

abnormal vibrissae reflex ( J:110607 )

• absent

tremors ( J:110607 )

• severe tremors seen by P12

abnormal motor coordination/balance ( J:110607 )

ataxia ( J:110607 )

• evident by P12

impaired balance ( J:110607 )

• difficulty maintaining position when the cage is shaken and unable to stand on a stationary or rotating rod

decreased grip strength ( J:110607 )

• unable to grip an inverted wire

head bobbing ( J:110607 )

abnormal gait ( J:110607 )

• wobbly gait

hearing/vestibular/ear

impaired hearing ( J:110607 )

• profound hearing loss

growth/size/body

decreased body size ( J:110607 )

• adults are about half the size of control littermates

postnatal growth retardation ( J:110607 )

• begin to lag behind littermates around P10

nervous system

abnormal prepulse inhibition ( J:110607 )

• absent