Phenotypes Associated with This Genotype

Genotype
MGI:3641105

• Allelic Composition: Fgfr2^tm1Dor/Fgfr2^tm1Dor; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal astrocyte morphology ( J:110263 )

• numbers of astrocytes reaching the cortex is significantly reduced compared to controls at P7; greatest loss (60%) is in the upper cortical layers with 22% loss in the subcortical white matter

• there is an intermediate reduction (39%) in astrocte density was seen in the inferior cortical layers

abnormal brain morphology ( J:110263 )

• mice show a subtle reduction in cortical size compared to control mice

cellular

abnormal astrocyte morphology ( J:110263 )

• numbers of astrocytes reaching the cortex is significantly reduced compared to controls at P7; greatest loss (60%) is in the upper cortical layers with 22% loss in the subcortical white matter

• there is an intermediate reduction (39%) in astrocte density was seen in the inferior cortical layers