Phenotypes Associated with This Genotype

Genotype
MGI:3641103

• Allelic Composition: Fgfr1^tm1Upir/Fgfr1^tm1Upir; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal astrocyte morphology ( J:110263 )

• idusium griseum astroglia are absent in the anterior regions of mutants

• processes emerging from the glial wedge and ventricular zone remain attached at the ventricular zone and the pia and very few astrocytes are observed in between the glial wedge and the idusium griseum

• numbers of astrocytes reaching the cortex are significantly reduced compared to controls

abnormal neuronal migration ( J:110263 )

• in mutants, midline cells do not migrate from the ventricular zone to the subpial region of the dorsomedial pallium

abnormal brain commissure morphology ( J:110263 )

• average midline width of the dorsal commissures is markedly smaller compared to controls; anterior and posterior are significantly more affected than the middle

abnormal corpus callosum morphology ( J:110263 )

• in 83% of mice, there is a complete loss of callosal axons from the motor and somatosensory cortex at birth

abnormal hippocampal commissure morphology ( J:110263 )

• there is a loss of hippocampal commissural axons in neonatal mice

cellular

abnormal astrocyte morphology ( J:110263 )

• idusium griseum astroglia are absent in the anterior regions of mutants

• processes emerging from the glial wedge and ventricular zone remain attached at the ventricular zone and the pia and very few astrocytes are observed in between the glial wedge and the idusium griseum

• numbers of astrocytes reaching the cortex are significantly reduced compared to controls

abnormal neuronal migration ( J:110263 )

• in mutants, midline cells do not migrate from the ventricular zone to the subpial region of the dorsomedial pallium