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Phenotypes Associated with This Genotype
Genotype
MGI:3640652
Allelic
Composition
Resttm1And/Resttm1And
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1And mutation (0 available); any Rest mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes begin to die between E9.5 and E10.5

embryo
• at E9.5-10, widespread apoptosis precedes embryonic lethality
• at E9.5 ~20% of homozygous embryos are smaller than normal; by E10.5, all null embryos exhibit growth retardation
• at E9.25, myotomal cells are disorganized and separated from the dermomyotome by a gap

growth/size/body
• at E9.5 ~20% of homozygous embryos are smaller than normal; by E10.5, all null embryos exhibit growth retardation

cellular
• at E9.5-10, widespread apoptosis precedes embryonic lethality

nervous system
• at E9.5, ~20% of homozygotes display small telencephalic vesicles
• head mesenchyme of the midbrain displays cellular disorganization and ectopic blood cells are present


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory