Phenotypes Associated with This Genotype

Genotype
MGI:3640652

• Allelic Composition: Rest^tm1And/Rest^tm1And
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:50169 )

• homozygotes begin to die between E9.5 and E10.5

embryo

increased embryonic tissue cell apoptosis ( J:50169 )

• at E9.5-10, widespread apoptosis precedes embryonic lethality

embryonic growth retardation ( J:50169 )

• at E9.5 ~20% of homozygous embryos are smaller than normal; by E10.5, all null embryos exhibit growth retardation

abnormal somite development ( J:50169 )

• at E9.25, myotomal cells are disorganized and separated from the dermomyotome by a gap

growth/size/body

embryonic growth retardation ( J:50169 )

• at E9.5 ~20% of homozygous embryos are smaller than normal; by E10.5, all null embryos exhibit growth retardation

cellular

increased embryonic tissue cell apoptosis ( J:50169 )

• at E9.5-10, widespread apoptosis precedes embryonic lethality

nervous system

small embryonic telencephalon ( J:50169 )

• at E9.5, ~20% of homozygotes display small telencephalic vesicles

abnormal midbrain development ( J:50169 )

• head mesenchyme of the midbrain displays cellular disorganization and ectopic blood cells are present