Rest^tm1And
Targeted Allele Detail

Summary

• Symbol: Rest^tm1And
• Name: RE1-silencing transcription factor; targeted mutation 1, David J Anderson
• MGI ID: MGI:3640355
• Synonyms: Rest^-, Rest^deltaN
• Gene: Rest Location: Chr5:77413338-77434279 bp, + strand Genetic Position: Chr5, 41.61 cM
• Alliance: Rest^tm1And page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50169
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the ATG and the sequence encoding the first four zinc fingers. Western blot failed to detect protein in mutant ES cells. (J:50169)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rest Mutation: 95 strains or lines available

References

• Original: J:50169 Chen ZF, et al., NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis [see comments]. Nat Genet. 1998 Oct;20(2):136-42
• All: 3 reference(s)