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Phenotypes Associated with This Genotype
Genotype
MGI:3640354
Allelic
Composition		 Cd40lgtm1Flv/Cd40lgtm1Flv
Genetic
Background		 NOD.129S2-Cd40lgtm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Flv mutation (1 available); any Cd40lg mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased regulatory T cell number ( J:93421 )
• mice display moderate but significant reduction in numbers of Tregs compared to NOD controls
decreased susceptibility to autoimmune diabetes ( J:93421 )
• mice do not develop diabetes

hematopoietic system
decreased regulatory T cell number ( J:93421 )
• mice display moderate but significant reduction in numbers of Tregs compared to NOD controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory