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Phenotypes Associated with This Genotype
Genotype
MGI:3640114
Allelic
Composition
Slc6a4tm1Kpl/Slc6a4tm1Kpl
Genetic
Background
B6.129-Slc6a4tm1Kpl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a4tm1Kpl mutation (3 available); any Slc6a4 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• traveled a significantly shorter distance in the open field
• spent significantly less time in the center of the open field
• showed exaggerated immobility in response to repeated, but not acute, exposure to the tail suspension test
• buried significantly fewer marbles than control
• male mutant mice spend more time in an empty cage than in a cage with a strange mouse in the sociability choice test; female mutant mice did not behave differently than controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:192363


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory