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Phenotypes Associated with This Genotype
Genotype
MGI:3639741
Allelic
Composition		 Malt1tm1Mak/Malt1tm1Mak
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1tm1Mak mutation (1 available); any Malt1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:109545 )
• purified T lymphocytes fail to expand or produce Il2 when stimulated with antiCD3 +/- antiCD28 costimulation; they do not respond to stimulation with PMA
decreased IgG level ( J:109545 )
• immunization with keyhole limpet hemocyanin doe not induce any production of KLH-specific IgG in mutants compared to wild-type
• IgG3 responses against TNP-Ficoll are absent for at least 21 days
decreased IgM level ( J:109545 )
• immunization with keyhole limpet hemocyanin doe not induce any production of KLH-specific IgM in mutants compared to wild-type
• IgM responses against TNP-Ficoll are absent for at least 21 days
abnormal dendritic cell physiology ( J:111706 )
• impaired zymosan-induced production of Tnfa in bone marrow dendritic cells
• impaired fungal cell-induced production of Tnfa, Il2, and Il10 in bone marrow dendritic cells

hematopoietic system
decreased T cell proliferation ( J:109545 )
• purified T lymphocytes fail to expand or produce Il2 when stimulated with antiCD3 +/- antiCD28 costimulation; they do not respond to stimulation with PMA
decreased IgG level ( J:109545 )
• immunization with keyhole limpet hemocyanin doe not induce any production of KLH-specific IgG in mutants compared to wild-type
• IgG3 responses against TNP-Ficoll are absent for at least 21 days
decreased IgM level ( J:109545 )
• immunization with keyhole limpet hemocyanin doe not induce any production of KLH-specific IgM in mutants compared to wild-type
• IgM responses against TNP-Ficoll are absent for at least 21 days

cellular
decreased T cell proliferation ( J:109545 )
• purified T lymphocytes fail to expand or produce Il2 when stimulated with antiCD3 +/- antiCD28 costimulation; they do not respond to stimulation with PMA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory