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Phenotypes Associated with This Genotype
Genotype
MGI:3639678
Allelic
Composition		 Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129-Ldlrtm1Her Gpr132tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (23 available)
Ldlrtm1Her mutation (21 available); any Ldlr mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atherosclerotic lesions ( J:100498 )
• area in lesions occupied by macrophage is significantly increased
• reduced collagen content
• decreased apoptosis of macrophage in lesions

immune system
decreased macrophage apoptosis ( J:100498 )
• decreased apoptosis of macrophage in atherosclerotic lesions

cellular
decreased macrophage apoptosis ( J:100498 )
• decreased apoptosis of macrophage in atherosclerotic lesions

hematopoietic system
decreased macrophage apoptosis ( J:100498 )
• decreased apoptosis of macrophage in atherosclerotic lesions

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory