Phenotypes Associated with This Genotype

Genotype
MGI:3639494

• Allelic Composition: Rnf111^{Gt(Betageo)1Vep}/Rnf111^{Gt(Betageo)1Vep}
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:68833 )

• embryos die around midgestation

embryo

failure of initiation of embryo turning ( J:68833 )

• homozygotes fail to undergo turning

embryonic growth arrest ( J:68833 )

• at somite stages, anterior development arrests; embryos rarely develop beyond 15 somites

abnormal neural tube morphology ( J:68833 )

• at sheadfolds appear narrower than normal at ~E9.5

• neurectoderm truncation extends to the anterior limit of its expression at rhombomere 2

nervous system

abnormal neural tube morphology ( J:68833 )

• at sheadfolds appear narrower than normal at ~E9.5

• neurectoderm truncation extends to the anterior limit of its expression at rhombomere 2

abnormal brain development ( J:68833 )

• mutants have a reduced head