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Phenotypes Associated with This Genotype
Genotype
MGI:3629516
Allelic
Composition		 Cd4tm1Mak/Cd4tm1Mak
Tnftm2Gkl/Tnf+
Genetic
Background		 involves: 129S/SvEv * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Mak mutation (5 available); any Cd4 mutation (85 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:108572 )
• there is high incidence of mortality in mice by age of 2-3 months

immune system
small intestinal inflammation ( J:108572 )
• mice show exacerbation of IBD compared to Tnftm2Gkl/+ mice

digestive/alimentary system
small intestinal inflammation ( J:108572 )
• mice show exacerbation of IBD compared to Tnftm2Gkl/+ mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory