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Phenotypes Associated with This Genotype
Genotype
MGI:3629232
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (9 available)
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• overall survival is extended 64 days (J:109131)
• overall survival is extended 64 days (J:109131)

nervous system
• in transgenic mice expressing a motorneuron specific Cre, disease onset is delayed 18 days (J:109131)
• progression from onset through early disease is delayed 31 days (J:109131)
• later disease progression is slowed with an average extension of 15 days (J:109131)
• in transgenic mice expressing a motorneuron specific Cre, disease onset is delayed 18 days (J:109131)
• progression from onset through early disease is delayed 31 days (J:109131)
• later disease progression is slowed with an average extension of 15 days (J:109131)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:109131


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory