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Phenotypes Associated with This Genotype
Genotype
MGI:3629207
Allelic
Composition		 Trp53tm1Tyj/Trp53+
Trp53bp2tm1Xlu/Trp53bp2+
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2tm1Xlu mutation (0 available); any Trp53bp2 mutation (52 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:108701 )
• 26% of double heterozygotes develop tumors over a 72 week period
increased lymphoma incidence ( J:108701 )
• lymphoma development is accelerated in compared to Trp53 heterozygotes with wild-type Trp53bp2; at 42 weeks there is a significant difference in the onset between the two genotypes
• at 72 weeks the difference in onset of lymphoma development is not significant

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory