Phenotypes Associated with This Genotype

Genotype
MGI:3629034

• Allelic Composition: Foxo1^tm1Whb/Foxo1⁺; Pdpk1^tm1Maka/Pdpk1^tm1Maka; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:109010 )

• double mutants have improved blood glucose levels compared to Pdk1-deficient mice; glucose levels of 200-300 mg/dl are maintained in double mutants at 20-24 weeks

increased circulating insulin level ( J:109010 )

• plasma insulin level is significantly higher in double mutants compared to Pdk1-deficient mice

endocrine/exocrine glands

increased pancreatic beta cell number ( J:109010 )

• Foxo-haploinsufficiency results in a significant increase in beta cell number in double mutants

abnormal pancreas physiology ( J:109010 )

• insulin content of the pancreas in double mutant mice is 6-fold higher than in Pdk1-deficient mice; number of proliferating beta cells is much greater in double mutants compared to Pdk1-null mice