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Phenotypes Associated with This Genotype
Genotype
MGI:3629034
Allelic
Composition
Foxo1tm1Whb/Foxo1+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Ins2-cre)23Herr/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Whb mutation (0 available); any Foxo1 mutation (12 available)
Pdpk1tm1Maka mutation (0 available); any Pdpk1 mutation (119 available)
Tg(Ins2-cre)23Herr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• double mutants have improved blood glucose levels compared to Pdk1-deficient mice; glucose levels of 200-300 mg/dl are maintained in double mutants at 20-24 weeks
• plasma insulin level is significantly higher in double mutants compared to Pdk1-deficient mice

endocrine/exocrine glands
• Foxo-haploinsufficiency results in a significant increase in beta cell number in double mutants
• insulin content of the pancreas in double mutant mice is 6-fold higher than in Pdk1-deficient mice; number of proliferating beta cells is much greater in double mutants compared to Pdk1-null mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory