Mouse Genome Informatics
cn
    Foxo1tm1Whb/Foxo1+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Ins2-cre)23Herr/0

involves: 129S4/SvJae * C57BL/6J * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• double mutants have improved blood glucose levels compared to Pdk1-deficient mice; glucose levels of 200-300 mg/dl are maintained in double mutants at 20-24 weeks
• plasma insulin level is significantly higher in double mutants compared to Pdk1-deficient mice

endocrine/exocrine glands
• Foxo-haploinsufficiency results in a significant increase in beta cell number in double mutants
• insulin content of the pancreas in double mutant mice is 6-fold higher than in Pdk1-deficient mice; number of proliferating beta cells is much greater in double mutants compared to Pdk1-null mice

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:109224