Phenotypes Associated with This Genotype

Genotype
MGI:3628814

• Allelic Composition: Prkacb^tm1Gsm/Prkacb^tm1Gsm
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

reduced long-term potentiation ( J:31731 )

• mutants are unable to maintain a potentiated response upon high-frequency stimulation, resulting in a late phase of long-term potentiation that is only 30% of controls, however paired-pulse facilitation is unaffected

absent long-term depression ( J:31731 )

decreased synaptic depression ( J:31731 )

• low-frequency stimulation fails to produce lasting synaptic depression as it does in wild-type