Phenotypes Associated with This Genotype

Genotype
MGI:3626326

• Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1Afst
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:107403 )

• before E11.5

• Background Sensitivity: increasing the amount of C57BL/6 in the strain background results in a slight reduction in the severity of the phenotype

nervous system

open neural tube ( J:107403 )

• seen at E9.5 in most homozygotes

• Background Sensitivity: increasing C57BL/6 content decreased this phenotype

kinked neural tube ( J:107403 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:107403 )

• growth is slowed at E6.5 and development is retarded by E7.5

• E9.5 is the 8 somite stage

embryo

embryonic growth retardation ( J:107403 )

• growth is slowed at E6.5 and development is retarded by E7.5

• E9.5 is the 8 somite stage

open neural tube ( J:107403 )

• seen at E9.5 in most homozygotes

• Background Sensitivity: increasing C57BL/6 content decreased this phenotype

kinked neural tube ( J:107403 )

• at E9.5

abnormal somite development ( J:107403 )

• Meox1 expression is initiated normally but then lost from the anterior most somites and somites seem to disappear resulting in kinking of the neural tube

cellular

increased apoptosis ( J:107403 )

• widespread apoptosis is seen at E9.5