Phenotypes Associated with This Genotype

Genotype
MGI:3626211

• Allelic Composition: Rbp4^tm1Gott/Rbp4^tm1Gott
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

trabecula carnea hypoplasia ( J:82903 )

abnormal myocardium compact layer morphology ( J:82903 )

abnormal heart valve morphology ( J:82903 )

• at E10.5, mutant hearts show no discernible differences in chamber identity or cardiac looping; no evidence of cardia bifida, atrial expansion or sinus venosus obliteration is observed

• however, mutant hearts display excessive fibronection deposition in cardiac jelly at E9.0 through E10.5 and in valves of the outflow tract and atrioventricular canal at E12.5

• notably, increased fibronectin deposition is caused by altered synthesis and/or degradation of fibronectin protein as opposed to increased fibronectin transcript levels

abnormal fetal cardiomyocyte proliferation ( J:82903 )

muscle

trabecula carnea hypoplasia ( J:82903 )

abnormal myocardium compact layer morphology ( J:82903 )

abnormal fetal cardiomyocyte proliferation ( J:82903 )

cellular

abnormal fetal cardiomyocyte proliferation ( J:82903 )