Phenotypes Associated with This Genotype

Genotype
MGI:3626001

• Allelic Composition: Yy1^tm1Yshi/Yy1^tm2Yshi
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:108369 )

• all mice that survive until birth die within 48 hours

lethality throughout fetal growth and development, incomplete penetrance ( J:108369 )

• about 25% of mice die between E13.5 and E14.5 and another 25% die between E16.5 and E19.5

respiratory system

respiratory failure ( J:108369 )

• pups isolated at E19.5 fail to inflate their lungs despite visible breathing efforts

cellular

decreased cell proliferation ( J:108369 )

• MEFs proliferate slower and produce smaller colonies

• Cre mediated recombination of the floxed allele produced a decrease in colony number and size and stopped proliferation by blocking cytokinesis

homeostasis/metabolism

cyanosis ( J:108369 )

• live born pups appear cyanotic

integument

pallor ( J:108369 )

• live born pups appear pale