Phenotypes Associated with This Genotype

Genotype
MGI:3625475

• Allelic Composition: Ptk2^tm1Lfr/Ptk2^tm1Ilic; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased sebaceous gland number ( J:107206 )

• a significant deficit in sebaceous glands in 2-4 month-old mice

integument

decreased keratinocyte proliferation ( J:107206 )

• primary keratinocytes isolated from mutant animals would not proliferate in culture

decreased sebaceous gland number ( J:107206 )

• a significant deficit in sebaceous glands in 2-4 month-old mice

sparse hair ( J:107206 )

• from approximately postnatal day 7 until P17, initial hair growth was sparse

• by P17, the pelage of mutant mice appeared identical to their normal littermates

abnormal hair follicle orientation ( J:107206 )

• hair follicles are orientated randomly, rather than being arrayed in a hexagonal pattern as in control in P12 mice

decreased hair follicle number ( J:107206 )

• have consistently about 25% fewer hair follicles than control

abnormal hair cycle ( J:107206 )

• irregular hair cycle suggested by the presence of hair follicles in the hypodermis of P22 mice

• adult mutant mice periodically showed patches of receding hair, which lasted for several days, disappeared, and then appeared again at another location

thin epidermis ( J:107206 )

• a thinner epidermis was evident in mutant mice at all ages

cellular

decreased keratinocyte proliferation ( J:107206 )

• primary keratinocytes isolated from mutant animals would not proliferate in culture