Analysis Tools
liver/biliary system
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• in cultured hepatocytes treated with poly(I)poly(C) 80% of anaphase cells have sister chromatids that fail to properly disjoin so that mitosis produces cells with micronuclei and abnormally large nuclei
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• after a injection with 400 ul poly(I)poly(C) and a two thirds hepatectomy, liver regeneration occurs but cells are larger, contain larger nuclei, and increased DNA content (many cell with 8C, 16C,or 32C DNA content) suggesting that regeneration occurs by genome replication without cell proliferation
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hematopoietic system
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• 3 days after a injection with 400 ul poly(I)poly(C) severe bone marrow aplasia is seen with only erythrocytes present; however, by 31 days after injection bone marrow cell numbers return to normal (all of these new hematopoeitic cells contain unrecombined alleles)
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