About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3625140
Allelic
Composition
Prkar1atm1Gsm/Prkar1a+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1atm1Gsm mutation (1 available); any Prkar1a mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Tumors in Prkar1atm1Gsm/Prkar1a+ mice

cardiovascular system
• depressed heart rate variability, however exhibit no heart rate changes, conduction delay or any cardiac myxomas (J:93393)
• depressed heart rate variability, however exhibit no heart rate changes, conduction delay or any cardiac myxomas (J:93393)

reproductive system
(J:93393)
(J:93393)

tumorigenesis
• increase in frequency of extracardiac tumors; 12 of 17 mutants developed tumors (J:93393)
• increase in frequency of extracardiac tumors; 12 of 17 mutants developed tumors (J:93393)
• 5 of 12 mutants that develop tumors have hepatocellular carcinomas (J:93393)
• 5 of 12 mutants that develop tumors have hepatocellular carcinomas (J:93393)
• 3 of 12 mutants that develop tumors have soft tissue sarcomas with myxomatous differentiation invading the calvaria (J:93393)
• 2 of 12 mutants that develop tumors have paraspinal and spinal sarcomas (chondro- and meningeal saracomas) with cord compression and lower limb paralysis (J:93393)
• 3 of 12 mutants that develop tumors have soft tissue sarcomas with myxomatous differentiation invading the calvaria (J:93393)
• 2 of 12 mutants that develop tumors have paraspinal and spinal sarcomas (chondro- and meningeal saracomas) with cord compression and lower limb paralysis (J:93393)
• 2 of 12 mutants that develop tumors have s.c. soft tissue myxoid fibrosarcomas of the forelimb (J:93393)
• 2 of 12 mutants that develop tumors have s.c. soft tissue myxoid fibrosarcomas of the forelimb (J:93393)
• 4 of 12 mutants that develop tumors have hemangiosarcomas of the spleen with myxoid regions (J:93393)
• splenic hemangiosarcomas are associated with metachronous lesions including colonic, ovarian, and pulmonary hemangiosarcomas (J:93393)
• 4 of 12 mutants that develop tumors have hemangiosarcomas of the spleen with myxoid regions (J:93393)
• splenic hemangiosarcomas are associated with metachronous lesions including colonic, ovarian, and pulmonary hemangiosarcomas (J:93393)

pigmentation
N
• pigmentation is normal (J:93393)
• pigmentation is normal (J:93393)

Mouse Models of Human Disease
OMIM ID Ref(s)
Carney Complex, Type 1; CNC1 160980 J:93393


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory