Mouse Genome Informatics
ht
    Prkar1atm1Gsm/Prkar1a+
involves: 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Tumors in Prkar1atm1Gsm/Prkar1a+ mice

cardiovascular system
• depressed heart rate variability, however exhibit no heart rate changes, conduction delay or any cardiac myxomas

reproductive system

tumorigenesis
• increase in frequency of extracardiac tumors; 12 of 17 mutants developed tumors
• 5 of 12 mutants that develop tumors have hepatocellular carcinomas
• 3 of 12 mutants that develop tumors have soft tissue sarcomas with myxomatous differentiation invading the calvaria
• 2 of 12 mutants that develop tumors have paraspinal and spinal sarcomas (chondro- and meningeal saracomas) with cord compression and lower limb paralysis
• 2 of 12 mutants that develop tumors have s.c. soft tissue myxoid fibrosarcomas of the forelimb
• 4 of 12 mutants that develop tumors have hemangiosarcomas of the spleen with myxoid regions
• splenic hemangiosarcomas are associated with metachronous lesions including colonic, ovarian, and pulmonary hemangiosarcomas

pigmentation
N
• pigmentation is normal (J:93393)

Mouse Models of Human Disease
OMIM IDRef(s)
Carney Complex, Type 1; CNC1 160980 J:93393