Phenotypes Associated with This Genotype

Genotype
MGI:3624966

• Allelic Composition: Slc6a9^tm1.1Bois/Slc6a9^tm1.1Bois; Tg(Camk2a-cre)2834Lusc/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:106967 )

• mutants exhibit reduced sensitivity to the motor stimulant effect of amphetamine and phencyclidine compared to control mice; the effect of amphetamine is delayed in the mutant while the response to phencyclidine is strongly attenuated compared to control

abnormal active avoidance behavior ( J:106967 )

• mutant mice show enhanced acquisition of active avoidance with an augmented latent inhibition effect in the testing paradigm used

abnormal conditioned taste aversion behavior ( J:106967 )

• mutants show enhanced expression of conditioned taste-aversion with an augmented latent inhibition effect in the testing paradigm used

abnormal cued conditioning behavior ( J:106967 )

• mutants exhibit and ehanced expression of conditioned tone-freezing with an augemented latent inhibition effect in the testing paradigm used

abnormal latent inhibition of conditioning behavior ( J:106967 )

• augmented latent inhibition in conditioned freezing, conditioned active avoidance, and conditioned taste aversion tests

nervous system

enhanced NMDA-mediated synaptic currents ( J:106967 )

• in conditional mutants at P21-30, a 2.15-fold enhancement of the NMDA/AMPA response ratio compared to control is measured in brain slices