Phenotypes Associated with This Genotype

Genotype
MGI:3624769

• Allelic Composition: Hr^m1Enu/Hr^m1Enu
• Genetic Background: BALB/cJ-Hr^m1Enu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

granulomatous inflammation ( J:108173 )

• skin of mutants shows granulomatous inflammation of the dermis associated with rupture of follicles

integument

dermal cyst ( J:108173 )

• 4-month old mutants have deep dermal cysts, upon examination of the middorsal skin

alopecia ( J:108173 )

• homozygous mutants begin losing hair around the face and neck, proceeding caudally, until mutants are devoid of all general body hair by 25 days of age

deformed nails ( J:108173 )

• nails are excessively long and curved

loss of vibrissae ( J:108173 )

• numbers of whiskers in homozygous mice decreases with age

abnormal epidermal layer morphology ( J:108173 )

• at 4 months of age, mutant skin is characterized by the formation of epidermal utricles

abnormal epidermis stratum corneum morphology ( J:108173 )

• generalized orthokeratosis affects the skin of the entire body in mutants

acanthosis ( J:108173 )

• generalized acanthosis affects the skin of the entire body in mutants

loose skin ( J:108173 )

• as mutants age, the skin becomes progressively looser, developing folds and flaps

growth/size/body

dermal cyst ( J:108173 )

• 4-month old mutants have deep dermal cysts, upon examination of the middorsal skin