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Phenotypes Associated with This Genotype
Genotype
MGI:3624687
Allelic
Composition		 Cdkn1btm1Mlf/Cdkn1btm1Mlf
Tg(KRT5-CDK4)2303Mlrp/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB * SENCAR * SSIN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm1Mlf mutation (2 available); any Cdkn1b mutation (25 available)
Tg(KRT5-CDK4)2303Mlrp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged thymus ( J:107588 )
• mutants have increased thymic lymphocyte cellularity
thymus hyperplasia ( J:107588 )
• mutants develop massive thymic hyperplasia; thymuses are 4-fold larger than those of Cdkn1b-null mice and 6-fold larger than Cdk4-deficient mice

hematopoietic system
enlarged thymus ( J:107588 )
• mutants have increased thymic lymphocyte cellularity
thymus hyperplasia ( J:107588 )
• mutants develop massive thymic hyperplasia; thymuses are 4-fold larger than those of Cdkn1b-null mice and 6-fold larger than Cdk4-deficient mice

endocrine/exocrine glands
enlarged thymus ( J:107588 )
• mutants have increased thymic lymphocyte cellularity
thymus hyperplasia ( J:107588 )
• mutants develop massive thymic hyperplasia; thymuses are 4-fold larger than those of Cdkn1b-null mice and 6-fold larger than Cdk4-deficient mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory