Mouse Genome Informatics
cn
    Mecp2tm1Jae/Y
Tg(Camk2a-cre)93Kln/0

involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• mutants appear healthy for up to 3 months when they begin to exhibit an ataxic gait (J:67909)
• mutants appear healthy for up to 3 months when they begin to show reduced nocturnal activity (J:67909)

growth/size
• 7 of 11 become overweight and obese at 10 weeks of age or older (J:67909)
• mutants appear healthy for up to 3 months when they begin to gain weight (J:67909)

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 7.5 months of age (J:67909)
• exhibit smaller neuronal bodies in the cortex and hippocampus but not in the cerebellum (J:67909)

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:67909