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Phenotypes Associated with This Genotype
Genotype
MGI:3624685
Allelic
Composition
Mecp2tm1Jae/Y
Tg(Camk2a-cre)93Kln/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (25 available)
Tg(Camk2a-cre)93Kln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants appear healthy for up to 3 months when they begin to exhibit an ataxic gait
• mutants appear healthy for up to 3 months when they begin to show reduced nocturnal activity

growth/size/body
• 7 of 11 become overweight and obese at 10 weeks of age or older
• mutants appear healthy for up to 3 months when they begin to gain weight

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 7.5 months of age
• exhibit smaller neuronal bodies in the cortex and hippocampus but not in the cerebellum

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:67909


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory