Phenotypes Associated with This Genotype

Genotype
MGI:3624260

• Allelic Composition: Hpgds^tm1Urad/Hpgds^tm1Urad
• Genetic Background: B6.129-Hpgds^tm1Urad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymph node morphology ( J:107651 )

• in response to BSA or concanavalin A, lymph node cellular proliferation is significantly greater in cultures from mutant mice at all time points compared to wild-type controls

abnormal cytokine secretion ( J:107651 )

• in response to BSA or concanavalin A, Il-2 levels in lymph node cultures from mutants are much higher than in cultures from control mice at 24 hours

increased inflammatory response ( J:107651 )

• upon injection of BSA into sensitized mutants, swelling of the paw is apparent after 1 hour, significantly greater at all time points and fails to resolve by 96 hours compared to controls

increased acute inflammation ( J:107651 )

• paws of mutants show increased neutrophil infiltrate than in wild-type mice in response to an inflammatory challenge; neutrophils accumulate subcutaneously in foci of keratin crust and form small subcorneal microabcesses not detected in wild-type

increased susceptibility to type I hypersensitivity reaction ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit increased dye extravasation (a measure of edema) compared with wild-type mice

integument

mixed cellular infiltration to dermis ( J:107651 )

• in the dermis and skeletal muscle of some mutants, there are dense accumulations of neutrophils forming small microabcesses not detected in wild-type

homeostasis/metabolism

edema ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit increased dye extravasation (a measure of edema) compared with wild-type mice