Phenotypes for Art2a Art2b Cd38 MGI:3623961 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Art2a^tm1Fkn/Art2a^tm1Fkn Art2b^tm1Fkn/Art2b^tm1Fkn Cd38^tm1Lnd/Cd38^tm1Lnd
Genetic Background	NOD.129(B6)-Cd38^tm1Lnd Art2a^tm1Fkn Art2b^tm1Fkn/Lt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Art2a^tm1Fkn mutation (2 available); any Art2a mutation (9 available)
Art2b^tm1Fkn mutation (3 available); any Art2b mutation (21 available)
Cd38^tm1Lnd mutation (4 available); any Cd38 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:108097 )

• double knockout NOD mice exhibit strong protection from diabetes in both sexes; female knockouts acquire diabetes at a frequency of 25% by 28 weeks compared to 100% in Cd38-null NOD females; double knockout NOD males are completely protected at 28 weeks compared to 100% incidence in Cd38-null NOD males

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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