Mouse Genome Informatics
hm
    Cd38tm1Lnd/Cd38tm1Lnd
NOD.129P2(B6)-Cd38tm1Lnd/LtJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• Cd38-deficient NOD mice display higher NAD-mediated T cell death
• insulitis progression in null NOD mice is accelerated at 9 weeks or later compared to wild-type NOD mice
• homozygous NOD mutants show significant acceleration in diabetes development compared to wild-type NOD mice; the first diagnosis of diabetes is made at 10 weeks of age while in wild-type NOD mice it occurs at 12 weeks or later; the frequency in null NOD males is 100% by 28 weeks which is higher than the frequency in wild-type NOD males
• diabetes acceleration is seen only when Cd38-deficient bone marrow from NOD mice is transferred to Cd38-deficient recipients
• diabetes onset is assessed by 2 consecutive positive urine glucose tests

endocrine/exocrine glands
• insulitis progression in null NOD mice is accelerated at 9 weeks or later compared to wild-type NOD mice

cellular
• Cd38-deficient NOD mice display higher NAD-mediated T cell death

hematopoietic system
• Cd38-deficient NOD mice display higher NAD-mediated T cell death

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:108097