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Phenotypes Associated with This Genotype
Genotype
MGI:3623958
Allelic
Composition
Cd38tm1Lnd/Cd38tm1Lnd
Genetic
Background
NOD.129P2(B6)-Cd38tm1Lnd/LtJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd38tm1Lnd mutation (4 available); any Cd38 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Cd38-deficient NOD mice display higher NAD-mediated T cell death
• insulitis progression in null NOD mice is accelerated at 9 weeks or later compared to wild-type NOD mice
• homozygous NOD mutants show significant acceleration in diabetes development compared to wild-type NOD mice; the first diagnosis of diabetes is made at 10 weeks of age while in wild-type NOD mice it occurs at 12 weeks or later; the frequency in null NOD males is 100% by 28 weeks which is higher than the frequency in wild-type NOD males
• diabetes acceleration is seen only when Cd38-deficient bone marrow from NOD mice is transferred to Cd38-deficient recipients
• diabetes onset is assessed by 2 consecutive positive urine glucose tests

endocrine/exocrine glands
• insulitis progression in null NOD mice is accelerated at 9 weeks or later compared to wild-type NOD mice

cellular
• Cd38-deficient NOD mice display higher NAD-mediated T cell death

hematopoietic system
• Cd38-deficient NOD mice display higher NAD-mediated T cell death

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:108097


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory