Phenotypes Associated with This Genotype

Genotype
MGI:3623951

• Allelic Composition: Gata6^tm2Msp/Gata6^tm2Msp; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:107814 )

• die between E18.5 and P1

cardiovascular system

abnormal cardiovascular system morphology ( J:107814 )

• exhibit a spectrum of aortic arch patterning and cardiac outflow tract septation defects indistinguishable from those seen in mice homozygous for Gata6^tm2Msp and hemizygous for Tg(Tagln-cre)1Jjl

retroesophageal right subclavian artery ( J:107814 )

aortic arch hypoplasia ( J:107814 )

• hypoplastic aortic arch

interrupted aortic arch ( J:107814 )

persistent truncus arteriosus ( J:107814 )

• seen as early as E9.5

double outlet right ventricle ( J:107814 )

perimembraneous ventricular septal defect ( J:107814 )

• membranous ventricular septal defect