Phenotypes Associated with This Genotype

Genotype
MGI:3623596

• Allelic Composition: Ighm^tm1Cgn/Ighm⁺; Tg(Igh-6/Igh-V125)2Jwt/0; Tg(Igk-C/Igk-V125)1Jwt/0
• Genetic Background: NOD.Cg-Ighm^tm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

insulitis ( J:91865 )

• the percentage of islets infiltrated is slightly increased in Igh-6-heterozygous transgenic mice

immune system

insulitis ( J:91865 )

• the percentage of islets infiltrated is slightly increased in Igh-6-heterozygous transgenic mice

increased susceptibility to autoimmune diabetes ( J:91865 )

• transgenic females heterozygous for Igh-6 develop diabetes (2 consecutive blood glucose measurements >200 mg/dl) at a slightly earlier time (12 weeks) than homozygous transgenic females but the incidence is the same by 17 weeks

homeostasis/metabolism

increased circulating glucose level ( J:91865 )