Mouse Genome Informatics
hm
    Ifngtm1Ts/Ifngtm1Ts
NOD.129S7(B6)-Ifngtm1Ts/DvsJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis
• when diabetic NOD splenocytes are transferred into mutant NOD mice, only 33% develop diabetes over the course of the observation period

endocrine/exocrine glands
• islet cells from Ifng-deficient NOD mice are less susceptible to insulin-specific CD8+ cell-induced toxicity

hematopoietic system
• CD8+ T cells injected into Ifng-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:72818