Phenotypes for Egfr Tgfa MGI:3623314 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Egfr^Wa5/Egfr⁺ Tgfa^tm1Unc/Tgfa^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfr^Wa5 mutation (2 available); any Egfr mutation (88 available)
Tgfa^tm1Unc mutation (3 available); any Tgfa mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Phenotypes of Egfr^wa2/Egfr^Wa5 and Tgfa^tm1Unc/Tgfa^tm1Unc Egfr^Wa5/⁺ mice

growth/size/body

small mandible ( J:92308 )

• smaller lower jaw

postnatal growth retardation ( J:92308 )

• reduced postnatal growth although size at birth is normal

• noticeably reduced in size by 1 week of age

• 25% reduction in body size in mice surviving to 6 weeks of age

craniofacial

small mandible ( J:92308 )

• smaller lower jaw

skeleton

small mandible ( J:92308 )

• smaller lower jaw

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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