Phenotypes Associated with This Genotype

Genotype
MGI:3623220

• Allelic Composition: Fgr^tm1Hev/Fgr^tm1Hev; Hck^tm1Hev/Hck^tm1Hev
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage morphology ( J:59037 )

• reduced numbers of filopodia and increased lamellopodia related membrane structures

• abnormal F-actin organization

abnormal macrophage physiology ( J:59037 )

• reduced tyrosine phosphorylation of adherent peritoneal exudate macrophage and in response to antibody crosslinking of alpha5 or beta1 integrin subunits

• impaired migration

impaired macrophage phagocytosis ( J:16994 )

• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis

increased susceptibility to bacterial infection ( J:16994 )

• impaired ability to resolve infection with Listeria monocytogenes

cardiovascular system

decreased angiogenesis ( J:89137 )

• angiogenic responses to Cxcl1 and Cxcl2 are disrupted

• neutrophile responses normal but they fail to release VEGF-A in response to Cxcl1 and Cxcl2

hematopoietic system

abnormal macrophage morphology ( J:59037 )

• reduced numbers of filopodia and increased lamellopodia related membrane structures

• abnormal F-actin organization

abnormal macrophage physiology ( J:59037 )

• reduced tyrosine phosphorylation of adherent peritoneal exudate macrophage and in response to antibody crosslinking of alpha5 or beta1 integrin subunits

• impaired migration

impaired macrophage phagocytosis ( J:16994 )

• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis

cellular

impaired macrophage phagocytosis ( J:16994 )

• of antibody labeled latex beads while antibody labeled sheep red blood cells undergo normal phagocytosis