Phenotypes Associated with This Genotype

Genotype
MGI:3622770

• Allelic Composition: Fas^lpr/Fas^lpr; Tg(INS-Il10)#Sar/0
• Genetic Background: NOD.Cg-Fas^lpr Tg(INS-Il10)#Sar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

insulitis ( J:64051 )

• islets of transgenic mice show extensive leukocytic infiltration compared to Fas-sufficient transgenic mice

increased susceptibility to autoimmune diabetes ( J:64051 )

• mice of the N3-4 and N8-9 NOD backcross develop accelerated diabetes with most developing diabetes by 10 weeks of age while lpr-deficient NOD mice are free from spontaneous insulitis and diabetes

• mice are considered diabetic after a blood glucose measure of >300 mg/dl

endocrine/exocrine glands

insulitis ( J:64051 )

• islets of transgenic mice show extensive leukocytic infiltration compared to Fas-sufficient transgenic mice