Phenotypes for Tg(INS-Il10)#Sar Tnfrsf1a MGI:3622768 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tg(INS-Il10)#Sar/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6J * NOD

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(INS-Il10)#Sar mutation (0 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:64051 )

• 60% of deficient transgenic mice develop diabetes by 5 weeks (blood glucose measuring >300 mg/dl), while 100% develop diabetes by 10 weeks compared to 0% of nontransgenic littermates

homeostasis/metabolism

increased circulating glucose level ( J:64051 )

• mice are considered diabetic after a blood glucose measure of >300 mg/dl

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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