Phenotypes Associated with This Genotype

Genotype
MGI:3622481

• Allelic Composition: Braf^tm1.1Sva/Braf^tm1.1Sva
• Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Embryonic development abnormalities in Braf^tm1.1Sva/Braf^tm1.1Sva mice

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:105998 )

• no viable homozygotes after E11.5

• embryos at E11.5 display extensive apoptosis in the liver, brain, and heart

growth/size/body

decreased embryo size ( J:105998 )

• embryos are significantly smaller than controls at E11.5

embryo

decreased embryo size ( J:105998 )

• embryos are significantly smaller than controls at E11.5

abnormal placenta morphology ( J:105998 )

• fetal part of placenta is thinner and less vascularized

abnormal placenta labyrinth morphology ( J:105998 )

• severely underdeveloped

abnormal placental labyrinth vasculature morphology ( J:105998 )

• few patent fetal blood vessels which fail to make proper contact with maternal blood sinuses

abnormal trophoblast layer morphology ( J:105998 )

• discontinuous giant trophoblast layer

abnormal spongiotrophoblast layer morphology ( J:105998 )

• discontinuous spongiotrophoblast layer

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:105998 )

• few patent fetal blood vessels which fail to make proper contact with maternal blood sinuses