| Image |
|
||||
| Caption | A: Phenotype of an E11.5 Braftm1.1Sva/Braftm1.1Sva fetus (lower) and wild type littermate (upper). Mutant embryos are developmentally retarded and smaller than their wild type littermates, and the placentae are less vascularized. B: Placental defects in mutant embryos. Hematoxylin and eosin stained radial sections of E11.5 and E10.5 placentae from wild type and mutant littermates are shown. In the mutant placentae, the spongiotrophoblast (Sp) and labyrinth layer (L) are severely underdeveloped and disorganized compared with wild type. (Top and Bottom) The dotted lines mark the boundaries between the labyrinth and the spongiotrophoblast layer and between the giant cell layer and the maternal decidua (De). (Insets) Higher magnifications. Thick filled arrows, giant cells; open arrows, hemorrhages. (Middle) Labyrinth architecture in wild type and muatnt E11.5 placentae. t, trophoblasts; s, stroma; thin filled arrows, endothelial cells; filled arrowheads, nucleated embryonic RBCs (red blood cells); open arrowheads, maternal RBCs. C: Massive apoptosis in mutant placenta at E11.5 revealed by TUNEL staining. (Lower) Adjacent sections stained with hematoxylin to show tissue structure. (D) proliferating cells (Ki67+, brown staining) are present in E10.5 wild type and mutant placentae. Scale bar, 500um. | ||||
| Copyright | This image is from Galabova-Kovacs G, Proc Natl Acad Sci U S A 2006 Jan 31;103(5):1325-30. Copyright 2006 National Academy of Sciences, U.S.A. J:105998 | ||||
|
Associated Alleles |
|
||||
|
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||
Analysis Tools