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Phenotypes Associated with This Genotype
Genotype
MGI:3622480
Allelic
Composition
Tg(Fabp4-Hsd11b1)7Jesf/0
Genetic
Background
FVB-Tg(Fabp4-Hsd11b1)7Jesf
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• develop visceral obesity that is further exaggerated by a high-fat diet
• body weights diverge after 9 weeks of age and by 15 weeks, mutants weigh 16% more than controls
• exhibit an increase in sensitivity to weight gain on a high-fat diet, with a 24% weight gain vs. 16% in controls

adipose tissue
• small increase in subcutaneous abdominal adipose tissue and a striking increase in mesenteric adipose tissue, however no differences in epididymal adipose tissue
• disproportionate accumulation of visceral fat depots
• adipocyte size in mesenteric or subcutaneous abdominal fat depots is increased 3.2-fold and 1.5-fold, respectively

behavior/neurological
• 10.2% increase in food intake

homeostasis/metabolism
• exhibit an increase in sensitivity to weight gain on a high-fat diet, with a 24% weight gain vs. 16% in controls
• leptin levels are disproportionately elevated, suggesting the development of leptin resistance
• exhibit insulin-resistant diabetes
• corticosterone levels are elevated 15-30% in adipose tissue and are increased 2.7-fold in portal vein, however see no differences in serum levels
• 3.3-fold increase in portal vein free fatty acid levels

Mouse Models of Human Disease
OMIM ID Ref(s)
Abdominal Obesity-Metabolic Syndrome 1; AOMS1 605552 J:107046


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory