Tg(Fabp4-Hsd11b1)7Jesf
Transgene Detail
|
Symbol: |
Tg(Fabp4-Hsd11b1)7Jesf |
Name: |
transgene insertion 7, Jeffrey S Flier |
MGI ID: |
MGI:3622478 |
Synonyms: |
aP2-HSD1 |
Transgene: |
Tg(Fabp4-Hsd11b1)7Jesf Location: unknown
|
Alliance: |
Tg(Fabp4-Hsd11b1)7Jesf page
|
|
|
Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(Fabp4-Hsd11b1)7Jesf expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
rat |
Hsd11b1 (25116) |
|
|
|
|
|
Mutation details: This transgene consists of the rat Hsd11b1 gene under the control of the enhancer-promoter region of the adipocyte fatty acid binding protein (Fabp4) gene. Hsd11b1 transcript is expressed equivalently in adipose tissue from subcutaneous, abdominal, epididymal, mesenteric, and interscapular brown adipose tissue depots but is absent in brain, liver, skeletal muscle and kidney. Hsd11b1 mRNA is increased 7-fold compared to endogenous mRNA and activity is increased 2.4-fold in subcutaneous abdominal fat and 2.7-fold in epididymal fat.
(J:107046)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:107046 Masuzaki H, et al., A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001 Dec 7;294(5549):2166-70 |
All: |
2 reference(s) |
|