Phenotypes Associated with This Genotype

Genotype
MGI:3622434

• Allelic Composition: Psmb8^tm1Hjf/Psmb8^tm1Hjf; Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:107657 )

• 30% reduction of CD8+ cells in the thymus

• reductions particularly involve cells expressing transgene coded TCR

• no alterations in CD4+ T cell

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:107657 )

• 30% reduction of CD8+ cells in the thymus

• reductions particularly involve cells expressing transgene coded TCR

• no alterations in CD4+ T cell