Analysis Tools
mortality/aging
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• homozygotes die between E11.5 and E15.5; no live homozygotes are recovered after E16.5
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• homozygotes die between E11.5 and E15.5, with frequent deaths noted at E13.5
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liver/biliary system
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• at E12.5, homozygotes often display hepatocyte apoptosis
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• at E12.5, homozygotes often display hepatocyte necrosis
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• at E12.5, homozygotes display absence of developing ducts
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• homozygotes exhibit defective fetal hepatogenesis
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• at E12.5, mutant livers display a hypoplastic epithelium with rounded, dissociated residual hepatocytes
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homeostasis/metabolism
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• 5 of 8 E12.5 homozygotes and 2 of 2 E13.5-E14.5 homozygotes exhibit generalized edema
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hematopoietic system
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• homozygotes show enhanced fetal liver erythropoiesis with elevated numbers of nucleated erythroid cells, resulting in an erythroblastosis-like phenotype
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nervous system
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• at E12.5, homozygotes exhibit severe edema in the forebrain, as shown by large intercellular spaces
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cardiovascular system
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• at E12.5, 1 of 8 homozygotes exhibited severely congested vessels and signs of early liver damage
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endocrine/exocrine glands
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• at E12.5, homozygotes display absence of developing ducts
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cellular
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• at E12.5, homozygotes often display hepatocyte apoptosis
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• at E12.5, homozygotes often display hepatocyte necrosis
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