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Phenotypes Associated with This Genotype
Genotype
MGI:3622153
Allelic
Composition
Aaastm1Ahue/Aaastm1Ahue
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aaastm1Ahue mutation (0 available); any Aaas mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• females, but not males, are infertile; however follicular development and ovulation appear to be normal (J:106908)
• females, but not males, are infertile; however follicular development and ovulation appear to be normal (J:106908)

behavior/neurological
• slight decrease in exploratory behavior for males in a light-dark transition assay and females during a wire hang task; however grip strength is normal and the total number of light dark transitions is similar to wild-type (J:106908)
• slight decrease in exploratory behavior for males in a light-dark transition assay and females during a wire hang task; however grip strength is normal and the total number of light dark transitions is similar to wild-type (J:106908)
• at 10 weeks of age, males fall of a rotating rod sooner than wild-type; however no significant difference is seen at any other age or in females at the same age (J:106908)
• at 10 weeks of age, males fall of a rotating rod sooner than wild-type; however no significant difference is seen at any other age or in females at the same age (J:106908)
• slightly less active in an open field; however, in a viewing jar and arena behavior appears normal and no abnormal reflexes are detected (J:106908)
• slightly less active in an open field; however, in a viewing jar and arena behavior appears normal and no abnormal reflexes are detected (J:106908)

growth/size/body
• decreased body weight at 8 and 10 weeks of age in female and male homozygotes, respectively (J:106908)
• decreased body weight at 8 and 10 weeks of age in female and male homozygotes, respectively (J:106908)

endocrine/exocrine glands
N
• histology of the adrenal gland, pituitary gland, ovary and testes appears normal (J:106908)
• histology of the adrenal gland, pituitary gland, ovary and testes appears normal (J:106908)

cellular
N
• nuclear pore complex structure and function in the liver, kidney and MEFs appears normal (J:106908)
• nuclear pore complex structure and function in the liver, kidney and MEFs appears normal (J:106908)

homeostasis/metabolism
N
• plasma levels of adrenocorticotropic hormone and corticosterone are similar to wild-type (J:106908)
• plasma levels of adrenocorticotropic hormone and corticosterone are similar to wild-type (J:106908)

nervous system
N
• peripheral nerve histology appears normal (J:106908)
• peripheral nerve histology appears normal (J:106908)

digestive/alimentary system
N
• histology of the esophagus appears normal (J:106908)
• histology of the esophagus appears normal (J:106908)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Achalasia-Addisonianism-Alacrima Syndrome; AAAS 231550 J:106908


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory