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Phenotypes Associated with This Genotype
Genotype
MGI:3622066
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tnftm2Gkl/Tnf+
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small intestinal inflammation ( J:54056 )
• only minimal intestinal inflammation is seen, unlike in mice heterozygous for Tnftm2Gkl only
rheumatoid arthritis ( J:54056 )
• arthritis is similar to mice heterozygous for Tnftm2Gkl only

digestive/alimentary system
small intestinal inflammation ( J:54056 )
• only minimal intestinal inflammation is seen, unlike in mice heterozygous for Tnftm2Gkl only

skeleton
rheumatoid arthritis ( J:54056 )
• arthritis is similar to mice heterozygous for Tnftm2Gkl only

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory