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Phenotypes Associated with This Genotype
Genotype
MGI:3622060
Allelic
Composition
Tnftm2Gkl/Tnftm2Gkl
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm2Gkl mutation (1 available); any Tnf mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between 5 and 12 weeks of age

cardiovascular system
• inflammation of the heart valves

immune system
• inflammation of the heart valves
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum
• becomes severe by 4 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall
• severe hypoplasia with atrophy and disorganization of the cortical and medullary areas is seen at 4 weeks of age; however at 12 days of age the ratio of thymic and peripheral T cell subsets is normal
• at 6 weeks of age circulating levels of TNF are up to 822 +/- 447 pg/ml compared to undetectable levels in wild-type mice
• develop signs of chronic polyarthritis including joint swelling, distortion of fore and hind paw morphology, impaired movement
• disease onset occurs at 12 days of age
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction
• both IgM and IgG are detected in arthritic joints

growth/size/body
• body weight does no exceed 6-7 g

digestive/alimentary system
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum
• becomes severe by 4 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall

skeleton
• develop signs of chronic polyarthritis including joint swelling, distortion of fore and hind paw morphology, impaired movement
• disease onset occurs at 12 days of age
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction
• both IgM and IgG are detected in arthritic joints

hematopoietic system
• severe hypoplasia with atrophy and disorganization of the cortical and medullary areas is seen at 4 weeks of age; however at 12 days of age the ratio of thymic and peripheral T cell subsets is normal

homeostasis/metabolism
• at 6 weeks of age circulating levels of TNF are up to 822 +/- 447 pg/ml compared to undetectable levels in wild-type mice

endocrine/exocrine glands
• severe hypoplasia with atrophy and disorganization of the cortical and medullary areas is seen at 4 weeks of age; however at 12 days of age the ratio of thymic and peripheral T cell subsets is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory