Analysis Tools
mortality/aging
| N |
• better survival after myocardial infarction than for wild-type controls
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• increased sensitivity to ionizing radiation
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cardiovascular system
| N |
• unlike mice null for Nos3, ischemia induced retinal neovascularization is not significantly different from controls
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• choroidal neovascularization following laser-induced rupture of Bruch's membrane is reduced
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• retinal revascularization after ischemia produces small highly branched blood vessels
• three fold more branching occurs in revascularization than occurs in controls
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• increased hyalination and patchy loss of cross-striations when on 100% oxygen
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• hypoxia causes less increase in the RV/LV+Septum ratio than is found in controls
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• left ventricular maximum developed pressure was similar to sham operated animals 4 months after myocardial infarction rather than being reduced as in wild-type controls
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• more significant drop in systolic blood pressure after myocardial infarction than is seen in controls
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vision/eye
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• choroidal neovascularization following laser-induced rupture of Bruch's membrane is reduced
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nervous system
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• shortened latency to seizures induced by kainic acid when on a normal diet
• behavior responses correspond to grade V seizures
• latency to seizure is prolonged when fed a ketogenic diet
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• decreased numbers of mature oligodendrocytes after cuprizone treatment
• numbers of oligodendrocytes reduced to 50% of controls after 3.5 weeks
• undergo increased apoptosis which is not seen for microglia and astrocytes
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• increased myelin pathology after treatment with cuprizone
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• recover better from compression injury to the spinal cord than do controls, severity of behavioral deficit due to injury is somewhat less
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digestive/alimentary system
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• less susceptibility to dextran sodium sulfate induced colitis
• less severe weight loss, blood loss and macroscopic damage
• improved survival
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homeostasis/metabolism
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• shorter time to thrombus formation and vessel occlusion
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• increased platelet deposition
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• no effect on streptozotocin induced diabetis
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• increased sensitivity to ionizing radiation
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• recover better from compression injury to the spinal cord than do controls, severity of behavioral deficit due to injury is somewhat less
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behavior/neurological
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• shortened latency to seizures induced by kainic acid when on a normal diet
• behavior responses correspond to grade V seizures
• latency to seizure is prolonged when fed a ketogenic diet
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• inhibitory effect of insulin on feeding is enhanced by 10 -8M TNF alpha
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• significantly more time spent in REM sleep during the light period
• increased REM sleep results from more REM episodes and shortened periods in between
• more non REM sleep episodes in light period but of shorter duration
• significantly less non REM sleep during dark periods
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respiratory system
| N |
• alveolar fluid clearance unaffected by amilorid and forskolin which both affect clearance in controls
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• increased ulceration in 100% oxygen than seen with controls
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• reduced lung injury relative to controls after 55 hours at 100% oxygen
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immune system
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• less susceptibility to dextran sodium sulfate induced colitis
• less severe weight loss, blood loss and macroscopic damage
• improved survival
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• elevated osteoclast surface to bone surface in comparison to controls 7 days after bone reloading
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hematopoietic system
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• elevated osteoclast surface to bone surface in comparison to controls 7 days after bone reloading
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• increased platelet deposition
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skeleton
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• less recovery of lost bone volume due to bone unloading 7 days after reloading
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• elevated osteoclast surface to bone surface in comparison to controls 7 days after bone reloading
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• lower mineral aposition rate than in controls 7 days after bone reloading
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muscle
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• increased hyalination and patchy loss of cross-striations when on 100% oxygen
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cellular
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• decreased numbers of mature oligodendrocytes after cuprizone treatment
• numbers of oligodendrocytes reduced to 50% of controls after 3.5 weeks
• undergo increased apoptosis which is not seen for microglia and astrocytes
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