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Phenotypes Associated with This Genotype
Genotype
MGI:3621470
Allelic
Composition
Hif1atm3Rsjo/Hif1atm3Rsjo
Tg(Ckmm-cre)5Khn/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm3Rsjo mutation (1 available); any Hif1a mutation (12 available)
Tg(Ckmm-cre)5Khn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• increase in muscle damage following exercise (J:97761)
• increase in muscle damage following exercise (J:97761)

homeostasis/metabolism
• increased serum levels of the MM isoform of creatine kinase 1 day after exercise (J:97761)
• increased serum levels of the MM isoform of creatine kinase 1 day after exercise (J:97761)
• significant decrease in lactate accumulation after exercise (J:97761)
• significant decrease in lactate accumulation after exercise (J:97761)
• increased endurance in swim tests and in the first session of running uphill (concentric exercise) but decreased endurance when running downhill (eccentric exercise) (J:97761)
• endurance decreased over 4 consecutive days of daily treadmill running (J:97761)
• increased endurance in swim tests and in the first session of running uphill (concentric exercise) but decreased endurance when running downhill (eccentric exercise) (J:97761)
• endurance decreased over 4 consecutive days of daily treadmill running (J:97761)

nervous system
• slight but statistically significant decrease in type IIa fibers in the soleus (J:97761)
• slight but statistically significant decrease in type IIa fibers in the soleus (J:97761)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory